Wormy Monkeys Had Healthier Intestines
















Click here to listen to this podcast


In developed countries, we’ve mostly eliminated freeloaders like parasitic worms from our guts. But we also have the highest rates of inflammatory bowel disease, or IBD—when the immune system mistakenly attacks intestinal cells and friendly gut bacteria.













For years, docs suspected there might be a connection between IBD and our worm-free lifestyle. And a handful of studies have actually shown that infecting human patients with worms can reduce symptoms of the disease. But how?


To find out, researchers fed parasitic worm eggs to monkeys with chronic diarrhea and gut inflammation—similar to IBD. After infection, the monkeys’ immune systems kicked into high gear, pumping out more mucus than usual to fight the worms. But that response also helped heal the monkeys’ intestines—restoring healthy, diverse populations of gut bacteria and decreasing the diarrhea. Those results appear in the journal PLoS Pathogens. [Mara Jana Broadhurst et al, Therapeutic Helminth Infection of Macaques with Idiopathic Chronic Diarrhea Alters the Inflammatory Signature and Mucosal Microbiota of the Colon]


The researchers already have FDA approval to study the worms in human subjects. Interested patients can go to clinicaltrials.gov to sign up—and hopefully worm their way out of intestinal distress.


—Christopher Intagliata


[The above text is a transcript of this podcast]
 


Follow Scientific American on Twitter @SciAm and @SciamBlogs. Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2012 ScientificAmerican.com. All rights reserved.


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Signs mount of possible Israeli invasion of Gaza

JERUSALEM (AP) — Israeli aircraft targeted rocket launching operations of Gaza militants early Friday as troops, tanks and armored personnel carriers massed near the Palestinian territory, signaling a ground invasion might be growing near.

Fighting between the two sides escalated sharply Thursday with a first-ever militant attack on the Tel Aviv area, menacing Israel's heartland. No casualties were reported there, but three people died in the country's rocket-scarred south when a projectile slammed into an apartment building.

The death toll in the densely populated Palestinian territory climbed to 19, including five children, according to Palestinian health officials, as waves of Israeli fighter planes and drones sent missiles hurtling down on suspected weapons stores and rocket-launching sites.

Early Friday, 85 missiles exploded within 45 minutes in Gaza City, sending black pillars of smoke towering above the coastal strip's largest city. The military said it was targeting underground rocket launching sites.

One missile hit the Interior Ministry, a symbol of Hamas power, and another hit an empty house belonging to a senior Hamas commander. Those strikes, together with an attack on a generator building near the home of Gaza's Hamas prime minister, Ismail Haniyeh, signaled that Israel was expanding its offensive beyond military targets.

The fighting has already widened the instability gripping a region in the throes of war and regime upheavals. It has straining already frayed relations with Egypt, which was sending its prime minister to Gaza later Friday in a show of solidarity with its militant Hamas rulers.

Israel and Hamas had largely observed an informal truce since Israel's devastating incursion into Gaza four years ago, but rocket fire and Israeli airstrikes on militant operations didn't halt entirely. The latest flare-up exploded into major violence Wednesday when Israel assassinated Hamas' military chief, following up with a punishing air assault meant to cripple the militants' ability to terrorize Israel with rockets.

The Israeli military reported early Friday that its aircraft had struck more than 350 targets since the beginning of its operation against Hamas' rocket operations.

After nightfall Thursday, several explosions shook Gaza City several minutes apart, a sign the strikes were not letting up. The military said the targets were about 70 underground rocket-launching sites.

The Israeli offensive has not deterred the militants from striking back with more than 400 rockets aimed at southern Israel. For the first time, they also unleashed the most powerful weapons in their arsenal — Iranian-made Fajr-5 rockets capable of reaching Tel Aviv.

The two rockets that struck closest to Tel Aviv appear to have landed in the Mediterranean Sea, defense officials said, and another hit an open area on Tel Aviv's southern outskirts.

No injuries were reported, but the rocket fire — the first in the area from Gaza — sowed panic in Tel Aviv and made the prospect of a ground incursion more likely. The government later approved the mobilization of up to 30,000 reservists for a possible invasion.

Israeli Prime Minister Benjamin Netanyahu said the army was hitting Hamas hard with what he called surgical strikes, and warned of a "significant widening" of the Gaza operation. Israel will "continue to take whatever action is necessary to defend our people," said Netanyahu, who is up for re-election in January.

At least 12 trucks were seen transporting tanks and armored personnel carriers toward Gaza late Thursday, and buses carrying soldiers headed toward the border area. Israeli TV stations said a Gaza operation was expected on Friday, though military officials said no decision had been made.

"We will continue the attacks and we will increase the attacks, and I believe we will obtain our objectives," said Lt. Gen. Benny Gantz, Israel's military chief.

An Israeli ground offensive could be costly to both sides. In the last Gaza war, Israel devastated large areas of the territory, setting back Hamas' fighting capabilities but also paying the price of increasing diplomatic isolation because of a civilian death toll numbering in the hundreds.

The current round of fighting is reminiscent of the first days of that three-week offensive against Hamas. Israel also caught Hamas off guard then with a barrage of missile strikes and threatened to follow up with a ground offensive.

Much has changed since then.

Israel has improved its missile defense systems, but it is facing a more heavily armed Hamas. Israel estimates the militants have 12,000 rockets, including more sophisticated weapons from Iran and from Libyan stockpiles plundered after the fall of Moammar Gadhafi's regime there last year.

Also, regional alignments have changed dramatically since the last Gaza war. Hamas has emerged from its political isolation as its parent movement, the region-wide Muslim Brotherhood, has risen to power in several countries in the wake of last year's Arab uprisings, particularly in Egypt.

Egypt recalled its ambassador to protest the Israeli offensive and ordered its prime minister to lead a senior delegation to Gaza on Friday in a show of support for Hamas.

At the same time, while relations with Israel have cooled since the toppling of longtime Egyptian leader Hosni Mubarak, Islamist President Mohammed Morsi has not brought a radical change in Egypt's policy toward Israel. He has promised to abide by Egypt's 1979 peace deal with Israel and his government has continued contacts with Israel through its non-Brotherhood members.

___

Laub reported from Gaza City, Gaza Strip.

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Egypt recalls envoy to Israel after Gaza strike
















CAIRO (AP) — Egypt has recalled its ambassador to Israel after an Israeli airstrike killed the military commander of Gaza‘s ruling Hamas.


In a statement read on state TV late Wednesday, spokesman Yasser Ali said that President Mohammed Morsi recalled the ambassador and asked the Arab League‘s Secretary General to convene an emergency ministerial meeting in the wake of the Gaza violence.













Morsi also called for an immediate cease fire between Israel and Hamas, an offshoot of Morsi’s Muslim Brotherhood. Israel says it struck in response to rocket attacks from Gaza.


Hours earlier, Morsi’s Muslim Brotherhood group denounced the Israeli airstrike as a “crime that requires a quick Arab and international response to stem these massacres.”


Relations between Israel and Egypt have deteriorated since longtime President Hosni Mubarak was ousted last year.


Middle East News Headlines – Yahoo! News



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Judge throws out Justin Bieber paparazzo chase case
















LOS ANGELES (Reuters) – Criminal charges filed against a photographer who pursued teen pop star Justin Bieber at high speeds on a Los Angeles freeway in July were thrown out on Wednesday, striking a blow to California’s crackdown on overly aggressive paparazzi.


Celebrity photographer Paul Raef was the first person to be prosecuted under the state’s 2010 law that criminalizes dangerous driving when taking photos commercially.













Raef was charged in July with two counts of violating the law stemming from a July 6 incident on a freeway in Los Angeles‘ San Fernando Valley.


Dismissing the charges, Los Angeles Superior Court Judge Thomas Robinson called the state’s anti-paparazzi law “problematic” and “overly inclusive.”


The law “sweeps very widely and would increase the penalties for reckless driving” in unintended cases, Robinson said.


Robinson faulted the law’s vague definition of commercial photography, saying that it could also apply to a photographer who was speeding to reach an arranged photo shoot with Bieber.


Raef could have faced up to a year in prison and $ 3,500 in fines, if convicted. His attorney, Brad Kaiserman, said the law is “about protecting celebrities.”


A message left with Bieber’s publicist requesting comment was not immediately returned.


Raef still faces lesser charges of misdemeanor reckless driving and failing to obey police orders after he allegedly pursued Bieber, 18, at high speeds. He will be tried on those charges at a later date.


Bieber, who was pulled over by police for driving 80 miles per hour in a 65 mph zone, told officers at the time that he was being hounded by paparazzi, and police said they noticed Raef’s car following the “Boyfriend” singer.


About 30 minutes after the traffic stop, Bieber called police to report that Raef continued to follow him. Police later found Raef and other paparazzi together in downtown Los Angeles.


The Canadian singer received a speeding ticket at the time.


(Reporting By Eric Kelsey, editing by Jill Serjeant and Sandra Maler)


Celebrity News Headlines – Yahoo! News



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Accused Colorado gunman tried to harm himself: reports
















CENTENNIAL, Colo. (Reuters) – Accused Colorado theater gunman James Holmes was taken to the hospital on Tuesday for a medical condition that left him unable to attend a court hearing set for two days later, his lawyers said, with local media reporting he had tried to harm himself.


The lawyers, explaining in vague terms in an emergency hearing on Wednesday the sudden developments that sent him to the hospital, requested a delay in a routine pre-trial hearing due on Thursday. There was no word on Holmes’ current condition.













“What occurred was midday yesterday. We were informed of a situation that involved a trip to a hospital,” Holmes’ attorney Tamara Brady said in court, giving scant further details but adding, “It’s not as simple as a migraine.”


Holmes, a 24-year-old former neuroscience graduate student, is accused of opening fire inside a suburban Denver movie theater during a midnight screening of the movie “The Dark Knight Rises” in July, killing 12 people and wounding 58 others.


The rampage was one of the bloodiest acts of gun violence in the United States in recent years.


Law enforcement sources told local television station CBS4 that Holmes made multiple “half-hearted” suicide attempts over the past few days, including one in which he ran into a wall in his jail cell and another in which he jumped off his bed.


Another local television station, ABC7, reported that Holmes was hospitalized after intentionally pounding his head on the walls and floor of his cell.


The station quoted sources familiar with the case as saying his actions were an indication of Holmes’ mental state, but did not constitute suicide attempts.


A judge approved the emergency defense request for a delay in the case, and set a new hearing for December 10. Holmes’ lawyers, in filing their request, did not provide details of Holmes condition, citing legal, medical and psychological privilege.


INSANITY DEFENSE?


“As a result of developments over the past 24 hours, Mr. Holmes is in a condition that renders him unable to be present in court for tomorrow’s hearing,” Holmes’ lawyers wrote in the delay motion.


Another of Holmes’ attorneys, public defender Daniel King, did not respond to reporters who asked if Holmes was still in the hospital.


Prosecutors had earlier objected to a delay, saying it should be denied unless more detailed information was provided on Holmes’ condition than was contained in the defense request.


“It is not clear whether it is claimed he is suffering from a physical medical condition, a mental condition, whether he is suffering from a negative emotional reaction to his circumstances, or anything other than he has some kind of ‘condition,’” prosecutors wrote in their response.


Prosecutors have depicted Holmes as a young man whose once promising academic career was in tatters at the time of the shooting. He failed oral board exams for graduate school in June and a professor suggested he may not have been a good fit for his competitive doctorate program.


Holmes then began a voluntary withdrawal from the school and amassed an arsenal of weapons as part of “a detailed and complex” plan to commit mass murder, prosecutors charge.


Holmes has yet to enter a plea in the case, and prosecutors have not indicated whether they will seek the death penalty.


Holmes’ lawyers, who analysts have suggested may be laying the groundwork for an insanity defense, have said Holmes suffers from mental illness and sought to get help before the shooting.


Arapahoe County Sheriff Grayson Robinson, asked about Holmes’ condition, told Reuters he could not release any information, citing privacy issues and jail security.


(Writing and additional reporting by Mary Slosson; Editing by Cynthia Johnston, Jim Loney and Peter Cooney)


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FBI terror expert started Petraeus probe













The FBI agent who investigated harassing emails to a Florida socialite, a probe that set off a chain of events leading to the resignation of CIA director David Petraeus over an extramarital affair, was a veteran investigator who has worked on high-profile terrorism cases.


The agent was identified as Frederick Humphries by a former federal agent, a source familiar with the Petraeus investigation and Humphries' attorney, Lawrence Berger.


Humphries, 47, received the initial complaint from Jill Kelley, 37, a Tampa, Fla., socialite, about "harassing" emails that an investigation traced back to Paula Broadwell, a 40-year-old author who co-wrote a biography of Petraeus, 60.


The investigation ultimately uncovered evidence of an affair between Broadwell and Petraeus, prompting Petraeus to resign last week.


Berger said his client's family "knew the Kelley family socially for several years." Jill Kelley asked Humphries for advice on what she perceived to be threatening e-mails and he "referred the matter to the bureau as appropriate."


Berger said his client has been wrongly characterized as a "whistleblower," but there is "no action pending against him, nor does he anticipate any future action."


Humphries "referred the matter to the FBI in accordance to proper protocol," Berger added, and the FBI investigation is taking its course.






AP Photo/Kevin P. Casey, AP Photo/Christopher Berkey, File











Classified Documents Taken from Alleged Petraeus Mistress' Home Watch Video









General John Allen's Relationship With Jill Kelley Watch Video









Gen. John Allen Scandal: Investigation of 'Inappropriate Relationship' Watch Video





Berger flatly declined to confirm or provide any details at all regarding Humphries' alleged contacts with the offices of either Rep. Dave Reichert, R-Wash., or House Majority Leader Rep. Eric Cantor, R-Va.


According to the New York Times, Humphries was allegedly concerned the case had been stalled for political reasons, and in late October contacted Reichert, whom he knew from his time working in Washington. The Times reported that Reichert put him in touch with Cantor, who then passed the message to FBI director, Robert Mueller.


An associate of Humphries told ABC News that it was hard to believe that Humphries had contacted elected officials about the case because "everyone knows that's professional suicide" and Humphries is "top notch."


Humphries has worked as a supervisor on Joint Terrorism Task Force in Tampa and has worked on high-profile terrorism cases.


In Seattle, Humphries worked the so-called Millenium terror plot in 1999, which prevented an Algerian al Qaeda member from bombing Los Angeles International Airport.


More recently, he testified in Florida in a terrorism case of Florida student Youssef Megahed and his associates.


In that case, back in 2007, a sheriff's deputy with the Berkeley County Sherriff's Office in South Carolina became suspicious when University of South Florida student Ahmed Mohamed and his companion, fellow USF student Megahed, did not initially stop when they were pulled over for speeding. The officer said he saw Megahed disconnect a power cord from a laptop computer as he approached the car. The deputy searched the vehicle. According to court records, he found safety fuses, several sections of cut PVC piping containing a potassium nitrate explosive mixture and containers filled with gasoline.


The pair was arrested that night for transporting explosives. Following the arrest, the FBI in Tampa and South Carolina began an investigation with the Joint Terrorism Task Force.






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General investigated for emails to Petraeus friend
















PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.


Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.













Panetta said that he ordered a Pentagon investigation of Allen on Monday.


A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.


Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.


Petraeus resigned as CIA director on Friday.


Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.


The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.


The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.


“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.


Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.


The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.


Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.


In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.


Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.


NATO officials had no comment about the delay in Allen’s appointment.


“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”


Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.


___


Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.


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Zynga CFO David Wehner deflects to Facebook
















NEW YORK (AP) — Zynga‘s finance chief is leaving the troubled online game company to join Facebook.


San Francisco-based Zynga Inc. said Tuesday that David Wehner will take a “senior finance position” at the social networking company. His exact title will be vice president of corporate finance and business planning, Facebook said.













Chief accounting officer, Mark Vranesh, is replacing Wehner as chief financial officer, returning to the post he held from 2008 to 2010, while Zynga was still a private company.


Zynga also reshuffled its executive ranks, a move CEO Mark Pincus said puts the company in a position for “long-term growth.” Zynga, whose games include “FarmVille” and “Texas HoldEm Poker,” has seen its stock price fall sharply in recent months amid concerns about its ability to make money from mobile games, off of Facebook.


David Ko, who was previously chief mobile officer, is now chief operations officer. Barry Cottle, who came to Zynga from Electronic Arts Inc., is now chief revenue officer. He was previously executive vice president of business and corporate development.


The appointments seek to fill some of the holes left by executives who’ve left Zynga in recent months. John Schappert, Zynga’s chief operating officer, left in August after less than a year and a half on the job. Schappert’s exit was followed by that of Mike Verdu, the company’s chief creative officer. And in September Jeff Karp, the chief marketing and chief revenue officer, left the company.


Zynga is also reaffirming its guidance. The company still expects adjusted earnings of 2 or 3 cents per share. Analysts polled by FactSet expect 3 cents.


Zynga shares closed up 1 cent at $ 2.11 and added 2 cents in after-hours trading.


Gaming News Headlines – Yahoo! News



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She’s got the voice, now Christina Aguilera looks for hits
















LOS ANGELES (Reuters) – Christina Aguilera has the vocal chops, the look, the strut and millions of new fans thanks to her stint as a judge on TV singing contest “The Voice.”


But can she still sell records?













The singer, who had global hits with “Genie in a Bottle” and the female empowerment ballad “Beautiful” more than 10 years ago, bids to reclaim her status as one of the world’s biggest pop stars with her new album, “Lotus,” released on Tuesday.


Aguilera, 31, says the title and the mixture of dance-pop, ballads and rock-tinged tracks reflect the hopes and disappointments of recent years that saw her 2010 tour for album “Bionic” canceled, a divorce and the box-office flop of her debut feature film, the musical “Burlesque.”


“Lotus represents the unbreakable flower that stands the test of time. No matter the roughest of weather conditions, it remains strong and continues to thrive. (The album) is a nod to my fans who have been here with me the whole journey, and a nod to myself,” she said.


“It is a record of freedom and embracing that…It is very artistic at times, it is very fun at times, it is very free. I think that’s how music and life should be, away from all the negativity,” the four-time Grammy winner said in an appearance at a Billboard Film and TV Music conference in Los Angeles last month.


Aguilera will perform one of the tracks – “Make the World Move” – with her fellow judge Cee Lo Green live on “The Voice” this week for the show’s more than 10 million viewers.


But music industry experts say Aguilera’s popularity on “The Voice” – where her powerhouse performances leave aspiring pop stars in the dust – may not guarantee huge album sales and won’t give the singer a No. 1 hit.


This week also sees new releases from British boy band One Direction and singer Susan Boyle as well as the new “Twilight” film soundtrack.


NOT A BLOCKBUSTER


“I think ‘Lotus’ will certainly debut in the top 10 on the Billboard 200 album chart. But we don’t see it as being a blockbuster out of the gate,” said Keith Caulfield, associate director of charts at Billboard.


“It is a long road to rebuilding Christina as a brand and as a musician, after the last album didn’t so very well,” said Caulfield. “But it’s not always about first week sales.”


Much like Jennifer Lopez on “American Idol,” Aguilera has seen her star rocket in her 18 months on “The Voice.” Just a few months before the TV show made its debut in spring 2011, Aguilera was arrested for being drunk in public in West Hollywood, and her 2010 album “Bionic” had sold a disappointing 312,000 copies.


“‘The Voice’ has reinvigorated her entire career. A lot of people think she is the star of ‘The Voice’ – the judge you tune in for,” said Lyndsey Parker, managing editor at Yahoo! Music.


Yet the first single – “Your Body” – from the new album failed to make a big impact when it was released in September. It peaked at No. 34 on the Billboard Hot 100 chart and never really caught fire on radio.


“It came and went, which surprised me because I think it is a very strong song. And pretty much everything I have heard on this album is strong. I think it’s a real return to form,” said Parker.


“There are very few people in pop who can sing like her. I do think there is a renewed appreciation for great singing that can be done live and that isn’t just about flash. And Christina is coming back to prove that. I think some people are looking at her to take back her crown,” Parker added.


“Lotus” includes duets with both Green and Aguilera’s fellow “Voice” judge, country singer Blake Shelton. It also features the piano-driven ballad “Blank Page,” which is reminiscent of her 2002 hit “Beautiful” and rock-tinged tracks like “Army of Me.”


Aguilera says she hopes to inspire a new generation of singers who were not around in 1999 for her first big hit “Genie in a Bottle.”


“It’s so exciting for me to show them what I do as an artist,” she said. “I’ve been through a lot over the past few years, going through ‘Burlesque,’ a divorce…having a few setbacks….Stuff happens! This is the business. It’s not going to be all cute and pretty and tied up in a bow.


“All of that combined is in ‘Lotus.’ It embraces the woman that I’ve become, and embracing myself coming full circle as a pop star,” she said.


(Additional reporting by Piya Sinha-Roy; Editing by Cynthia Osterman)


Music News Headlines – Yahoo! News



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Congress, Obama playing with dynamite, CEOs say of “fiscal cliff”
















BOSTON (Reuters) – Corporate America is raising the volume of its plea that the U.S. government avert a year-end “fiscal cliff” that could send the nation back into recession, but chief executives aren’t pushing the panic button just yet.


With a heated election season in the rear-view mirror, executives are calling on the White House and congressional leaders to head off a self-imposed deadline that could bring $ 600 billion in spending cuts and higher taxes early in 2013 if they are unable to reach a deal on cutting the federal budget deficit.













The Business Roundtable on Tuesday kicked off a print, radio and online ad campaign on which it plans to spend hundreds of thousands of dollars featuring the chiefs of Honeywell International Inc , Xerox Corp and United Parcel Service Inc calling on lawmakers to resolve the issue.


In an opinion piece published on Tuesday evening on the Wall Street Journal’s website, Goldman Sachs Chief Executive Officer Lloyd Blankfein urged the business community and the Obama administration to compromise and reconcile so as not to derail the fragile recovery.


One of the more dramatic warnings of the consequences of allowing the U.S. economy to go over the fiscal cliff came from Honeywell CEO David Cote.


“If the last debt ceiling discussion was playing with fire, this time they’re playing with nitroglycerin,” Cote said in an interview. “If they go off the cliff, I think it would spark a recession that’s a lot bigger than economists think. Some think it would just be a small fire. I think it could turn into a conflagration.”


The nonpartisan Congressional Budget Office (CBO) estimates that the U.S. economy would contract 0.5 percent in 2013 if the government fails to stop the budget cuts and tax increases – far below the 2 percent growth economists currently forecast.


A failure in Washington to solve the crisis by the year’s end could prompt major companies to curtail investment plans, said Duncan Niederauer, CEO of NYSE Euronext , operator of the New York Stock Exchange.


“We simply won’t be investing in the United States. We will be investing elsewhere where we have more certainty of the outcome,” Niederauer said in an interview.


About a dozen top U.S. CEOs, including General Electric Co’s Jeff Immelt, Aetna Inc’s Mark Bertolini, American Express Co’s Ken Chenault and Dow Chemical Co’s Andrew Liveris are scheduled to meet with President Barack Obama on Wednesday to discuss the issue.


The four are members of “Fix the Debt,” an ad-hoc lobbying organization that this week launched an advertising campaign that advocates long-term debt reduction.


UNCERTAINTY FACTOR


Bank of America Corp CEO Brian Moynihan said on Tuesday that worries about the cliff have companies holding off on spending.


“That uncertainty continues to hold back the recovery,” Moynihan said, speaking at an investor conference in New York.


Sandy Cutler, CEO of manufacturer Eaton Corp , shared his concern.


“Until we solve the fiscal issues (in the United States and Europe), you’re not going to get back to normal GDP growth,” Cutler told investors on Tuesday.


CEOs are not alone in this worry. The CBO report warned that failure to reach a deal could push the U.S. unemployment rate up to 9.1 percent, the highest since July 1991. It is currently 7.9 percent.


Obama and the Republican leadership of the House of Representatives have signaled a more conciliatory tone since last week’s election, when Obama soundly defeated Republican challenger Mitt Romney, whose party retained a majority in the House.


Wilbur Ross, an investor known for taking stakes in distressed companies, is bracing for higher tax rates in 2013.


“We, like many people, have been trying to utilize gains this year. It does seem that the probability is that rates will go up,” Ross said in an interview with Reuters Insider. “We don’t have a “for sale” sign on anything. But we are mindful that there is a benefit to concluding things this year rather than next.


NO SIGNS OF PANIC


Concerns about the cliff have not prompted customers to cancel orders, though they have added to an overall level of uneasiness that has companies wary of making large capital purchases or hiring significant numbers of new workers.


“We haven’t seen the panicking, like, ‘I’m not going to order something because of the fiscal cliff,’” said Steve Shawley, chief financial officer of heating and cooling systems maker Ingersoll Rand Plc . “Customers are being very judicious with their orders.”


Likewise, JPMorgan Chase & Co CEO Jamie Dimon last month told investors he did not expect the negotiations to hurt lending in the fourth quarter.


“The fiscal cliff isn’t going to change us,” Dimon said, referring to JPMorgan’s commercial bank, which loans money to businesses. The bank’s investment banking side could be more vulnerable if the debate makes investors jittery, he allowed.


WEAPONS, MEDICINES IN THE CROSS-HAIRS


The defense and healthcare sectors are the most vulnerable to the fiscal cliff, as they face the threat of sequestration — automatic, across-the-board cuts to their funding.


Makers of weapons systems note that they have long been preparing for declining sales as the United States winds down two long wars in Iraq and Afghanistan. The industry has already shed tens of thousands of jobs and closed facilities.


Lockheed Martin Corp’s new president and chief operating officer, Marillyn Hewson, told analysts on Monday her company had been preparing for tighter defense budgets for years, even before the sequestration deal.


“We aren’t going to see a major change,” said Hewson. “We’ve been very proactive as a leadership team in taking actions in recent years to address our cost structure, to look at how we can make our product more affordable.”


Automatic cuts to the federal budget could reduce federal health spending by $ 21.5 billion in 2013, potentially affecting everything from Medicare to the Food and Drug Administration, according to an analysis by PwC’s Health Research Institute.


Vincent Forlenza, the CEO of Beckton Dickinson & Co , said the labs he supplies have held off on buying new instruments because of the threat of spending cuts.


“If we don’t get to a deal we will have another year of paralysis and putting off research,” Forlenza said. “The impact of uncertainty on the (National Institutes of Health) budget is causing our research customers to put off research.”


(Additional reporting by John McCrank, Nick Zieminski, Caroline Humer, Jed Horowitz, Sharon Begley and Daniel Wilchins in New York, Rick Rothacker in Charlotte, North Carolina, Nichola Groom in Los Angeles, Andrea Shalal-Esa in Washington, Debra Sherman in Chicago and Anna Driver in Houston; Editing by Patricia Kranz and Steve Orlofsky and Carol Bishopric)


Health News Headlines – Yahoo! News



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